Hypoxia-Induced Proliferative Response of Vascular Adventitial Fibroblasts is Dependent on G- Protein Mediated Activation of MAP Kinases
نویسندگان
چکیده
*Supported by SCOR # HL 56481 and NIH # HL 14985. DMB was supported by NIH Training Grant # HL 07171. MD was supported by a postdoctoral fellowship from the American Heart Association, Arizona, Colorado and Wyoming Affiliate, a Giles Filley Research Award from the American Physiological Society, and a research grant from the American Lung Association. RN is supported by DK 39902, DK 19928 and HL 62924.
منابع مشابه
Protein kinase Czeta attenuates hypoxia-induced proliferation of fibroblasts by regulating MAP kinase phosphatase-1 expression.
We have previously found that hypoxia stimulates proliferation of vascular fibroblasts through Galphai-mediated activation of ERK1/2. Here, we demonstrate that hypoxia also activates the atypical protein kinase Czeta (PKCzeta) isozyme and stimulates the expression of ERK1/2-specific phosphatase, MAP kinase phosphatase-1 (MKP-1), which attenuates ERK1/2-mediated proliferative signals. Replicatio...
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